রবিবার, ৩০ সেপ্টেম্বর, ২০১২

Ryan: Gun Owners Should Fear an Obama Re-Election

COLUMBUS, Ohio ? Vice presidential candidate Paul Ryan courted the votes of hunters on Saturday in a speech to a sportsmen?s group, suggesting that President Obama would seek to strip gun owners of their rights by appointing judges hostile to a broad interpretation of the Second Amendment.

?I shudder as a gun owner ... what would he do if he never has to face the voters ever again?? Ryan asked aloud during a speech to the National U.S. Sportsmen?s Alliance?s 16th Annual Save Our Heritage Banquet here.

?The next president is going to pick a lot of judges. The next president will appoint a lot of different judges and these are lifetime appointments. If you want to make sure that judges respect our Second Amendment rights, you need a president who respects those rights as well,? he said.

Ryan likened gun ownership to religious liberty, suggesting that the federal government had intruded on people?s First Amendment rights as well. He also stressed the importance of appointing people to government agencies who will ?respect the rights of hunting and fishing,? and said that the widely criticized Fast and Furious gunwalking operation ?would never occur under a Romney-Ryan administration.?

He also responded to claims by Vice President Joe Biden on Friday that he and Romney could raise taxes on seniors receiving Social Security. The Obama campaign has sought to argue that because various analyses of Romney?s tax-cut plan suggest the tax burden would shift from wealthy to middle-class families, it is reasonable to assume that the shifted tax burden would fall on Social Security benefits.

But Romney has never said that he would raise taxes on Social Security benefits, and he has promised that he will not reduce Social Security benefits for current retirees. The Obama campaign has been making a similar argument using the Romney campaign?s Medicare plan.

Ryan said his and Romney?s plan makes no changes for those in or near retirement and that Biden himself had voted to raise taxes on seniors? benefits by supporting President Clinton?s 1993 budget ? tax increases that Obama voted to keep in place three times, he noted.

?Shame on the politician who wants to use this issue to try and scare seniors when those of us who are out there [are] trying to fix this problem for my generation and my kids? generation and your kids,? Ryan said.

Responding to Ryan's comments, Obama campaign spokesman Danny Kanner noted that Republican Gov. John Kasich said in introducing the House Budget Committee chairman that Ohio has added 123,000 jobs since 2011 "and is moving forward. But rather than building on the progress we'vemade under President Obama, Mitt Romney and Congressman Ryan would take us back."

Ryan?s appearance before the group Saturday evening underscores his role in the campaign as an ambassador to the middle class who better understands some traditions, such as hunting, with which Romney has less experience. Ryan is a former chairman of the Congressional Sportsmen?s Caucus for four years, and lauds the values he and his wife Janna have taught their children during hunting trips.

?You teach them patience, you teach them respect, you teach them conservation, the outdoors. You spend time with your kids,? Ryan said.

Source: http://news.yahoo.com/ryan-gun-owners-fear-obama-election-212204322--politics.html

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2 killed, 1 wounded at VFW lodge shooting

By NBC News

Two people were fatally shot and one was wounded Sunday morning at a Veterans of Foreign Wars lodge where motorcyclists had?gathered?for a charity ride to raise money for injured bikers, WESH.com reported.

The shooting occurred around 10:40 a.m. at the VFW Post 5405 in Winter Springs, Fla., about 15 miles northeast of Orlando. Police say the investigation remains in the early stages and that they believe they have the shooter in custody.

At the time, riders were finishing breakfast, about to embark on the charity ride, when armed men came in and started shooting, the Orlando Sentinel reported.


According to the Sentinel, police evacuated those in the building to a nearby senior center. They also detained several people and confiscated many weapons.

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Source: http://usnews.nbcnews.com/_news/2012/09/30/14160479-three-shot-at-vfw-lodge-in-florida-during-motorcycle-charity-ride?lite

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Ask Engadget: should companies include a cable with a new product?

Ask Engadget

We know you've got questions, and if you're brave enough to ask the world for answers, here's the outlet to do so. This week's Ask Engadget inquiry is from is from David, who wants to know if you'd prefer a free cable or a cheaper device when you buy pro audio gear. If you're looking to send in an inquiry of your own, drop us a line at ask [at] engadget [dawt] com.

"I work for a small audio-tech company and we're currently getting close to releasing out first retail product, which does surround sound from stereo inputs -- kinda like Dolby Pro Logic, except good. Internally, we're agonizing over if we should include a stereo RCA cable. Of course, users will need to integrate an additional cable into their set up, but plenty of people will have spares lying around at home. Do you think it's better to:

a) Include a cheap cable and let people who care buy a high quality one?
b) Include a reasonable quality cable but increase the price?
c) Include no cable and make it clear they need to buy one?

Many thanks!"

What a question! We're decidedly of two minds, since given a bit of haggling, most retailers will chuck in a branded lead, but we'd hate to get our shiny new gear home to find it's missing a key component the one time they don't. Our dithering aside, it's time to turn the question over to our faithful Engadgeteers with this chance to shape the future of the high-end audio business for the better, we'd better not disappoint the man!

Filed under: ,

Ask Engadget: should companies include a cable with a new product? originally appeared on Engadget on Sat, 29 Sep 2012 22:46:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/09/29/ae-bundle-cables/

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শনিবার, ২৯ সেপ্টেম্বর, ২০১২

Brooklyn kids get a jump on Halloween at the Ragamuffin Parade

Anna Cruz,2, dances with her cousin Xavier Curcio,3, at The 46th Annual Ragamuffin parade where youngsters dress up in their Halloween costumes and parade along 3rd Ave. from 76th street to 92nd street.Saturday,September 29, 2012 (Debbie Egan-Chin/New York Daily News photo) The 46th Annual Ragamuffin parade where youngsters dress up in their Halloween costumes and parade along 3rd Ave. from 76th street to 92nd street.Saturday,September 29, 2012 (Debbie Egan-Chin/New York Daily News photo)

Debbie Egan-Chin/New York Daily News

Anna Cruz, 2, dances with her cousin Xavier Curcio,3, at the 46th annual Ragamuffin Parade.

Goblins, ghouls, bumblebees and even Supergirl were on hand Saturday for the annual Ragamuffin Parade in Bay Ridge, Brooklyn.

Hundreds of kids, from tots to teens, marched down 3rd Ave. during the pre-Halloween bash.

And when it comes to costumes, the more unique, the better. Six creative kids won bikes this year for their Halloween garb.

vcavaliere@nydailynews.com

Source: http://feedproxy.google.com/~r/nydnrss/new-york/~3/xU6vM7U-I3s/story01.htm

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Egypt's president heads to Turkey to build emerging alliance of moderate Islamist governments

CAIRO - Egyptian President Mohammed Morsi travels to Turkey on Sunday to strengthen an emerging alliance between two moderate Islamist governments in a region beset by conflict and instability.

Even though Morsi has only been in power for a few months, there are already strong signs a partnership with Turkey is forming, evidenced by a common effort to end Syria's civil war by urging the exit of President Bashar Assad from power.

Earlier this month, Turkish Foreign Minister Ahmet Davutoglu visited the Egyptian capital Cairo and pledged $2 billion in aid to boost confidence in an economy badly battered by a tourism slump, strikes and ongoing protests since the fall of authoritarian leader Hosni Mubarak in an uprising last year.

During the 12-hour visit, Morsi will try to strengthen economic ties with Turkey ? a country his Muslim Brotherhood group views as an Islamist success story, mixing a strong economy with Western ties and Islamic piety.

Turkey, a NATO member with a mostly Muslim, but not Arab, population, has been touted as a democratic model for Egypt and other Arab countries swept up in popular revolts over the past two years.

After initially looking to the Turkish ruling party as a role model, the Islamic fundamentalist Brotherhood in Egypt has cooled to the idea because of Turkey's strong secular leanings. Morsi and the Brotherhood, on the contrary, have been criticized by their opponents for pushing a more conservative Islamist line, particularly in drafting the country's new constitution.

"Before the revolution, we saw (Turkish Prime Minister Recep Tayyip) Erdogan's regime ... as a successful model that can be emulated," said Dina Zakaria, a member of the foreign relations committee of the Muslim Brotherhood's Freedom and Justice Party. "But can it be with all its details and can it all suit Egyptian society? Of course not."

Turkish officials and media have voiced enthusiasm for the relationship with Cairo after the uprising. Turkish President Abdullah Gul was the first foreign leader to visit Egypt after Mubarak stepped down on Feb. 11, 2011, meeting with both the largely liberal and secular youth groups that spearheaded the pro-democracy revolt as well as with generals from the ruling military council who took over from Mubarak and then eventually transferred power to the democratically elected Morsi.

Erdogan got a warm welcome in Cairo last year, with crowds of Brotherhood supporters lining the airport road upon his arrival, some of them carrying banners reading: "Erdogan is a hero."

Erdogan has encouraged Egypt to mimic the Turkish model of governance.

But Zakaria said that after frequent visits to Turkey and meetings with different groups there, she is convinced Egyptian society would not accept Turkey's secular constitution.

Many in conservative Egypt equate the term secularism with "anti-Islam." As efforts to draft the country's constitution are marred by disputes over what many liberals perceive as overtly Islamist clauses in the charter, Zakaria ruled out drawing inspiration from the Turkish constitution.

"Their constitution won't work here in Egypt," she said. "There are things Egyptian people won't accept," she added, referring mainly to the separation of religion and he state.

One of the founding principles of Turkey's constitution is that it is a secular democracy, something that contradicts Egypt's old constitution, and is not even considered in the writing of the new charter. Debate remains in Egypt over whether to keep the current charter, which cites the principles of Islamic law as the basis of legislation, or to harden it to include a reference to specific Islamic laws which would guide all legislation.

But when it comes to foreign affairs and economics, there is much that Egypt can gain from Turkey's experience, Zakaria said.

Certainly on the international stage, Cairo and Ankara have much in common. Both want Assad of Syria to quit and Iran, his ally, to stay out of the civil war there. Ankara and Cairo have teamed as part of a regional initiative to try to solve the Syrian crisis, an effort that could form a strong foundation of future cooperation.

"Turkey couldn't do anything alone when it comes to Syria. One hand alone won't clap," Zakaria said. "What is clear now is that the two countries need to have strong relations because we have serious regional problems and we need each other."

Mustafa Ellabbad, an Egyptian expert on Turkish relations, said Turkey wants an Arab partner in its bid for regional influence in the Middle East and its affiliation with the Brotherhood would serve as a foundation for a moderate Islamist alliance. The Brotherhood, in return, looks to Turkey for assistance as a bridge to the West. But for some of Egypt's more radical Islamists, "the Turkish model doesn't even deserve to be labeled Islamic," Ellabbad said.

But Morsi could turn to Turkey for help on other domestic issues, chief among them the economy. He has already visited Saudi Arabia, Ethiopia, China, Iran, Italy and Belgium before his recent trip to New York, where he addressed the U.N. General Assembly. His frequent travels have raised criticism that he is paying more attention to foreign policy issues than domestic problems. However, the economic issues appear high on the agenda on most of his foreign trips.

"The economic portfolio is certainly one of the most important ones between Egypt and Turkey," Yasser Ali, the presidential spokesman, said Saturday.

Egypt's economy is faltering under the weight of shrinking foreign investment and numerous labor strikes demanding better wages and representation in state-owned companies. The political system remains far from stable, and a referendum on a new constitution and new parliamentary elections that will follow that will test the performance of the Brotherhood's Islamist politics.

This is where Morsi may turn to Turkey for inspiration.

Erdogan's Justice and Development Party, or AKP, has had an extraordinary record of electoral success and longevity, coming to power in 2002 amid economic hardship and a fractured political landscape, and then comfortably winning general elections again in 2007 and 2011.

Zakaria could not confirm local media reports that the AKP provided assistance to the Brotherhood's political party ahead of Egypt's parliamentary elections last year. Brotherhood officials told Egyptian media that the party's local branch in Alexandria, Egypt's second largest city, signed a partnership deal with the AKP in Istanbul, ahead of last winter's parliamentary elections.

Morsi is also expected to attend the annual congress of Turkey's ruling Justice and Development Party, a first for an Egyptian leader, and is invited to attend an economic forum organized by the Turkish chamber of commerce on Sunday.

Hassan Malek, a prominent businessman from the Muslim Brotherhood traveling to Turkey with Morsi, said there is much that Egypt can learn from Turkey in the fields of manufacturing, industry and trade zones. He said Egypt could particularly benefit in the fields of manufacturing apparel, and electronics.

Egypt's Minister of Economic Cooperation Ashraf el-Araby told local media that a committee at the level of prime ministers will be formed to push economic cooperation, including opening the African market for both countries. Trade between the two countries has already reached $3.8 billion in the first nine months of 2012, a 27 percent increase compared to the same period last year, said Turkey's ambassador to Egypt Hussein Awny. He estimated the figure could rise to reach $5 billion by the end of the year.

"It is not hidden that there is a meeting of minds. Geographically we are close, we have similar visions," Malek said. "This is a new opportunity. There are many things in the Turkish experience we can transfer and benefit from. But we can't copy everything."

___

Associated Press writers Chris Torchia and Suzan Fraser contributed to this report from Istanbul and Ankara.

Source: http://www.startribune.com/world/171926051.html

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Risk Reward Balanced at Masco - Zacks.com

We have maintained a Neutral recommendation on Masco Corporation (MAS - Analyst Report) following appraisal of second quarter 2012 results.

Masco Corporation?s adjusted earnings of 10 cents per share in the second quarter of 2012 missed the Zacks Consensus Estimate by a penny due to lower-than-expected revenues. However, earnings jumped 66% from the prior-year quarter.

Masco?s net sales of $2.0 billion in the reported quarter missed the Zacks Consensus Estimate of $2.08 billion. Revenues were flat with the prior-year quarter, hurt significantly by currency headwinds, slowing remodeling activity in the U.S. and challenges in the cabinetry business. Management also lowered its expectations for the second half due to volatility in North American repair/remodel markets and challenges in Europe.

Masco Corporation manufactures, sells, and installs home improvement and building products. Its main products and services include plumbing products, cabinets and related products, installation and other services, decorative architectural products, and other specialty products. The company is a leading cabinetry manufacturer in the U.S. and holds the largest share in faucets and kitchen cabinets. The company owns some of the popular brands like KraftMaid and Merillat cabinets, Delta and Hansgrohe faucets, Behr paint and Milgard windows.

Masco?s Cabinet business has been sluggish for sometime mainly because the repair and remodel spending trends have slowed in the U.S. and the dealer segment is not showing any major traction. Moreover, the company is facing challenges in Europe. As a result of continuous underperformance, management had to lower its profit expectations from this business for the second half of 2012.

Despite the short-term headwinds, we like the long-term fundamentals of Masco. We believe that the company?s leadership brands, its continued focus on innovation and new product launches can help drive growth in the long term.

Moreover, the U.S. housing industry which was until now fragile has begun to show some signs of improvement. Housing demand is improving, affordability is increasing and prices are stabilizing. As the housing conditions improve, demand for new home construction is gaining traction which will eventually lead to higher demand for repair, remodel activity.

The company undertook several strategic initiatives to cope with the challenging U.S. homebuilding industry and other headwinds like raw material cost inflation. The initiatives included the improvement of underperforming businesses like Installation and Cabinet; leveraging its brands and continued innovation, reducing costs and strengthening the balance sheet. Masco?s restructuring initiatives are almost done and are expected to result in about $175 million of gross cost reduction excluding the impact of inflation in 2012.

Read the full analyst report on MAS

Source: http://www.zacks.com/stock/news/83837/risk-reward-balanced-at-masco

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SD festival drawing filmmakers to middle America

ABERDEEN, S.D. (AP) ? It's a Friday night on Main Street in the small northern South Dakota town of Aberdeen, and it's supposedly a hopping one with the marquee event of the annual South Dakota Film Festival being held at the historic Capitol Theater.

And yet, the street is nearly empty. The chirping of crickets is only occasionally disturbed by passing cars or pedestrians. Cannes or Sundance, this is not.

Some might consider it an unfortunate side effect of being, well, in the middle of nowhere in South Dakota, in a town hugged by corn fields and the closest "big cities" ? Fargo, Bismarck, Sioux Falls and Pierre ? each being about three hours away.

But Tom Black doesn't see it that way.

"We're not the middle of nowhere. We're the middle of everywhere," said Black, a co-producer of the South Dakota Film Festival, which this weekend is in its sixth year.

Looking at a map, he's just about right. As long as film goers don't mind that cattle outnumber local residents, Aberdeen is pretty close to being smack dab in the middle of the country.

And it's that central location that has grown the small-town festival into a filmmakers' favorite, consistently drawing hundreds of people into the quaint-but-spacious theater each of the event's four days.

It's gotten so big, in fact, that organizers said they might need to spread to other downtown locations in the next year or two.

"It's charming here. It's a great theater," said Mike Scholtz, 42, of Minnesota, whose latest documentary "Wild Bill's Run" has won awards at both the South Dakota and Seattle film festivals. The "arctic crime caper" also has been accepted into the better-known Mountain Film Festival in Canada's Banff, Alberta.

"A lot of festivals are in hotel conference rooms, or just spaces that aren't as nice for film watching. This is a really nice space for it," Scholtz said.

Indeed, the Capitol Theater is the stuff of theatres past. Inside the lobby is an ornate chandelier and restored 1920s organ. The theater itself is adorned with turn-of-the-century embellishments and balcony seating. The screen pulls down over a true stage, one that's used for live performances by the Aberdeen Community Theatre.

It's a space Penny Stolsmark of Pierpont, S.D., has known since childhood ? but Friday marked the first time she and her husband have visited for the film festival.

"We had to come. We've never been to this before, but we always wanted to," Stolsmark said. "We're big moviegoers. I'm thinking if we really like it tonight, we might VIP it next year."

What drew Stolsmark to this year's festival wasn't a new film, but rather one celebrating its 20th anniversary: "Thunderheart" starring Val Kilmer and Native American actor Graham Greene. Greene is arguably best known for his role in another South Dakota-filmed movie, "Dances With Wolves," for which he was nominated for a best supporting actor Academy Award.

The showing, followed by a question-and-answer period with Greene, was to be one of the festival's highlights.

Saturday is to feature a preview of upcoming films made in South Dakota, a six-minute silent flick called "Bus 1107," a horror film called "Werewolf in a Girls Sorority," and what Black describes as this year's big get: "Butter," a film starring Jennifer Garner that won't be widely released until Oct. 5.

And that's just a sampling. About 100 filmmakers entered their works; about half of those were accepted, organizers said. Many of the films have cast or crew from the Upper Great Plains.

"We'll tear about 1,000 tickets over the course of the weekend," Black said.

Scholtz, who made his first film in 1997, said Aberdeen ? population 27,000 ? will continue to lure him because it's a "filmmakers' festival."

"Everyone in the film community in the Midwest is aware of the festival," he said. "Average people won't have heard of it, but they have a really good reputation with filmmakers."

Black said that while the festival is heavy on Great Plains artists, it also draws filmmakers from Florida, Washington state, Washington D.C., and the rest of the country. People don't just love showing their work in South Dakota, he said, they like making it here, too.

Not only does the state offer the picturesque landscape that made "Wolves" star Kevin Costner a lifelong fan, but it's cheap for film workers, Black said. South Dakota doesn't have the income tax, union labor or hefty sales tax of some other states, he said.

"You may think Chicago isn't the middle of nowhere, but it takes a lot longer to get to Chicago for most people," Black said. "We're actually the perfect place."

___

Online:

www.southdakotafilmfest.org

Source: http://news.yahoo.com/sd-festival-drawing-filmmakers-middle-america-083359941.html

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RVA-based LIVE ART documentary wins big with Kickstarter ...

LIVE Art logo

A feature documentary showcasing the people surrounding a unique education program and concert by the School of the Performing Arts in the Richmond Community (SPARC) has earned funding to support the film?s post-production. ?We feel a huge sense of responsibility,? said Bill Gaff of Humanstory films, one of the filmmakers involved in the project and a Midlothian resident. ?People truly want to see the film.?

The feature will document SPARC?s 20-week performing arts program, LIVE ART, that culminated with a June 3rd, 2012 performance at the Carpenter Theatre. It featured 125 students, musicians, and a surprise performance by Grammy Award-winner Jason Mraz, himself an alumnus of the SPARC program. Founded in 1981, SPARC offers classes for children of different ages that cultivate skills in the performing arts. The organization reaches over 700 students, with or without special needs, in over 25 area schools.

Gaff heard from Martin Montgomery, a Richmond-based filmmaker, about SPARC wanting to document the training and performance to inspire other communities across the country to create similar programs. The filmmakers attended classes and began speaking with both students, parents, and teachers. Gaff said he was impressed with the people involved, saying he ?never had an interaction with a group of people like that before.? He and the other producers were so moved, they asked themselves: Could this become an actual feature-length documentary? They thought it could.

?Our first priority was to get footage in the can,? said Gaff. He and Montgomery began shooting what Gaff estimates is over 200 hours of footage. ?We saw all these potential great characters,? he said. ?It really proved to be amazing.?

Gaff said that as a filmmaker: ?You always look for people in situations that change the course of their lives.? Seeing children?some of whom were deaf, autistic, or with Down syndrome?devote weeks to practice and preparation and the emotional capital invested by parents and educators showed filmmakers there was a story here. ?We knew we had something.?

Started on August 27th, the project?s Kickstarter funded nearly $34,000, well over the $20,000 goal. SPARC said it?s one of the top funding Kickstarter projects based in the Richmond region since January. ?SPARC and LIVE ART had such a strong community of people behind it,? said Gaff. That money will help fund the next several months of post-production work.

?We don?t know the extent of what we have,? said Gaff about the hours of footage the filmmakers have accumulated and that will need to be edited. Additionally, Gaff and others are still conducting interviews for the film. Marathon viewing sessions will take place over the coming months in which he and others will produce a four-hour rough cut. Gaff hopes that later, by February 2013, the filmmakers will have a more standard-length version of the film that they can submit to film festivals to secure a distribution deal.

Report an error or correction for this article using the form below. Thank you!

Nathan Cushing

Nathan Cushing is a writer, journalist, and RVANews Editor.

Source: http://rvanews.com/entertainment/rva-based-live-art-documentary-wins-big-with-kickstarter/68885

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HOLLYWOOD: LIFE IS A SCRIPT TO BE ... - One Citizen Speaking

What?s a hero to do when he finds that his story is a pack of lies?

In an attempt to recapture the essence of Silkwood, it appears that Matt Damon and his buddies latched on to an environmental story of potentially deadly and disgusting gross water pollution by evil oil companies using ?Fracking,? an allegedly dangerous procedure to obtain more oil from oil-bearing lands. Sounds perfect for a modern day environmental hero to be played by Matt Damon. So what could go wrong? THE UNDERLYING STORY WAS BASED ON A LIE ? AND MANIPULATION BY THE EVIL ENVIRONMENTALISTS.

Hollywood celebrity Matt Damon has been forced to do dramatic rewrites of his anti-fracking movie Promised Land after a series of court cases found the film was inspired by a number of frauds. The rewrites - to ensure that the movie had an anti oil and gas company stance - are revealed in an op/ed in the New York Daily Post by a journalist and filmmaker Phelim McAleer:

McAleer reveals that the rewrites came after a series of findings that environmentalists opposed to fracking had committed perjury or misrepresented their situation. As the cases became publicly known Damon and his fellow screenwriter John Krasinski (Jim in NBC's The Office) went to ludicrous lengths to avoid putting the spotlight on environmentalists who had been caught committing fraud as part of lucrative multi-million dollar lawsuits.

So what is a fundamentally intellectually dishonest filmmaker going to do?

This is Hollywood, where the facts only serve as a framework for a story ? it doesn?t have to be true, it just has to sound believable and give the hero plenty of time to pose ?looking like a hero.? So deprived of version one, the evil oil companies are polluting the land, we go on to version two. Version two sees the evil environmentalists committing fraud ? but in a plot twist ? are actually paid by the evil oil companies.

Damon and Krasinski wrote a script where they admit that environmentalists lie but claim that this deception is paid for by oil and gas companies to discredit the environmental movement.

"Matt Damon really has jumped the shark with Promised Land," said McAleer who is making FrackNation, a documentary about fracking.
"It seems Hollywood will go to any lengths to demonize the fossil fuel industry even making ludicrous assertions that they are funding the lawbreakers on the other side. It's crazy. Matt Damon is destroying what could be a good movie because of his environmental anti-business bias."

Bottom line ?

The public is being subtly conditioned to believe the environmentalists, a movement which has been infiltrated by ideological socialists and communists to continue their work of destroying America from within. With the help, of course, of ?useful idiots? in the Hollywood community who see only their own ability to gain media attention and big dollar rewards. Never once thinking about what they might be doing to the nation?s rather uneducated masses who actually believes what they are told by the Hollywood liberals.

In the final analysis, it is all about making a movie ? profits, recognition and the opportunity to speak as ?an expert? in various forums, including Congressional hearings where the bar for ?experts? providing testimony (especially without being sworn) is absurdly low.

Take a moment to read ?Matt Damon?s troubled frack attack?Phelim McAleer - NYPOST.com? and consider how the environmentalists are subverting our own laws to finance their political actions and to bring down the America we know and love.

Perhaps Matt Damon should reunite with Ben Affleck and write an original movie based on Hollywood?s ?useful idiots? and the propaganda they spew.

-- steve

Source: http://www.onecitizenspeaking.com/2012/09/hollywood-life-is-a-script-to-be-manipulated-by-matt-damon-to-push-liberal-ideology.html

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Cultured

Cultured

What if you were made to die?

Owner:

Game Masters:

This topic is an Out Of Character part of the roleplay, ?Cultured?. Anything posted here will also show up there.

Topic Tags:

Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.
Welcome to "Cultured"

Thankyou for viewing my roleplay, and I hope you will consider taking part.
Here feel free to make reservations, ask questions and discuss the roleplay.

Please note, this is a literate, and advanced rp, so I will be rather strict on character profiles. My own characters stand as examples of what I am expecting. Since this is literate (again, pointing this out (: ) roleplay, if you are not willing/prepared to write around 600 words for each of your posts, please don't join.
About the reservations, they last 24hours and people can reserve the same character and compete if needed.

User avatar
Shan?
Member for 1 years



This could be interesting. Inspired by The Island I assume?

Staring real hard at the available slots. Might make a character should inspiration strike.

User avatar
Seirei
Member for 2 years


Haha. I hope you find one you like, I tried to make all the spots as interesting as each other :) I actually haven't heard of that film though I'd assume that since cloning is a rather intriguing and controversial topic many different stories would be made about it.

User avatar
Shan?
Member for 1 years


Oh please, please, please let me reserve The One in Denial! I really want to join this :)

I have this theory that, depending on your attitude,
your life doesn't have to be this ridiculous charade
that it seems so many people end up living.

- Christian Bale

Death is more universal than life; everyone dies but not everyone lives.

raindrops_autumn
Member for 0 years



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A small college cancels ACS journal subscriptions: Here's why this matters

A few weeks ago, Jenica Rogers, the library director at SUNY Potsdam, a small public college in upstate New York, wrote a blog post detailing how her library and chemistry department decided to cancel subscriptions to the journals published by the American Chemical Society due to unsustainable costs. Faculty at SUNY Potsdam agreed that it was worthwhile to forego immediate access to that content, even though it?s of high quality. Continued access to ACS journals would have used up 10% of the total library acquisitions budget. To make up for the loss of ACS journals they added subscriptions to journals from the Royal Society of Chemistry and other publishers.

The American Chemical Society is well known in library circles for having aggressive year-to-year price increases. Last year, my library cancelled its subscription to the ?all ACS journals? package in favor of a new, smaller, package of 16 ACS journals to avoid an effective 11% price jump on the ?all journals? package. The year before our cost for the ACS archive (pre-1995 journals) doubled as the ACS moved to a new pricing model. While prices for the smaller journal package held steady for us this year, I keep a list of things that we might need to cancel when (not if) prices increase faster than the library budget. I?m concerned that we will have to cancel this smaller journal package in favor of just a few ACS subscriptions sometime in the next few years. After several years of declining or steady library budgets, my library has made all of the ?easy? cuts we can in order to afford scholarly content from the ACS and other publishers: the book budget has been slashed, we?ve cancelled many magazines and newspapers, the student worker budget has been cut, we aren?t binding print journals anymore, etc. Other libraries are in a similar position where the only thing left to cut are journal subscriptions.

Many folks have responded to Potsdam?s move on library and chemistry blogs and other news sites (John Dupuis has a good list of posts and commentary). Some applaud their actions as standing up to the ?Goliath? of publishers. Others lament that their students will lose access to high quality research published by ACS. Few ask about the non-chemistry students who would loose access to their own discipline?s high quality research in order for Potsdam to afford the ACS subscriptions. Every time journal subscription costs go up faster than library budgets, something has to be cut.

For many folks, subscriptions to these journals were once considered un-cancelable. Perhaps we?ve been pushed to the point now where that is no longer the case.

In a recent article in the Chronicle of Higher Education the author talked to Jenica, a chemistry faculty member, and reached out to the ACS about the issue, expanding on some of the issues raised in Jenica?s original blog post. The ACS seemed to say that they aren?t going to talk to us about this in the places where we talk about this:

?We find little constructive dialogue can be had on blogs and other listservs where logic, balance, and common courtesy are not practiced and observed,? Glenn S. Ruskin, the group?s director of public affairs, said in an e-mail message. ?As a matter of practice, ACS finds that direct engagement via telephone or face-to-face with individuals expressing concern over pricing or other related matters is the most productive means to finding common ground and resolution.?

This statement infuriated many mild mannered librarians. Librarians use blogs, listservs, and other new-fangled online communication tools to discuss library issues, to help each other out and to engage with publishers on issues of mutual interest.

After several chemistry librarians politely expressed their outrage and disappointment in the ACS on the chemical information societies listerv, Mr. Ruskin emailed a response, stating that a final sentence had been left off his quote:

?Therefore, we will not be offering any response to this blog posting or the conversation that has ensued.?

His explanation suggested that the ACS was not going to respond to Jenica?s blog post and this particular issue. I?m not sure that Mr. Ruskin?s clarification seems to help the matter. Whatever your feelings about the tone of Jenica?s blog post (or her previous posts about the ACS in which she has described herself as ?feeling pointy?), Mr. Ruskin is still saying that they aren?t going to talk about this issue in the places where librarians talk about issues like this.

Personally, I don?t blame Jenica for using blunt language and the occasional curse word when talking about ACS with friends and colleagues. I became a librarian because I love information, and I?m passionate about teaching students to access, understand and use the scientific literature. When publishers make it more difficult for students to access it by charging fees that we can no longer afford, I feel ?pointy? too. Just ask the librarians whose cubicles are next to mine.

Those of us struggling to provide our students and faculty with high quality research are frustrated that we don?t have partners on the other side of the table willing to engage with us in honest conversation about journal prices. We are left with few options: renew at the prices ACS is charging or cancel something. It isn?t a nice position to be in.

Talk to us, ACS. And I don?t mean by calling me privately. Engage with librarians and chemists about this issue on listservs and blogs. Open a dialog on what a reasonable pricing model would include. We know that you have good content, and we?re not expecting to access it for free. But when we can?t afford it anymore we are left with few options, and almost everyone loses. I would love to see a greater variety of journal package options (a package of 8 or 12 journals, for example) at a lower cost. I would like to see some honest figures about why my college?s cost per download is about 10 times the cost per download of our nearby university. I would also love to hear about how the aggressive price increases and higher-than-other-scholarly-societies subscription costs mesh with the mission statement of the ACS ?to advance the broader chemistry enterprise and its practitioners for the benefit of Earth and its people.?

Don?t shut down the public conversation.

?

Source: http://rss.sciam.com/click.phdo?i=f0e6c54b26a91cb69c016197751750f1

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Social bullying prevalent in children's television

Thursday, September 27, 2012

Children ages 2-11 view an alarming amount of television shows that contain forms of social bullying or social aggression. Physical aggression in television for children is greatly documented, but this is the first in-depth analysis on children's exposure to behaviors like cruel gossiping and manipulation of friendship.

Nicole Martins, Indiana University, and Barbara J. Wilson, University of Illinois, Urbana-Champaign, published in the Journal of Communication a content analysis of the 50 most popular children's shows according to Nielsen Media Research. One hundred and fifty television shows were viewed and analyzed, and 92% of the programming contained some version of social aggression?approximately 14 times per hour. There was careful attention to what was portrayed in the cases of social aggression, whether the behavior was rewarded or punished, justified, or committed by an attractive perpetrator.

The findings suggested that some of the ways in which social aggression is contextualized make these depictions particularly problematic for young viewers. The study found that attractive characters who perpetrated social aggression were rarely punished for their behavior, and that socially aggressive scenes were significantly more likely than physically aggressive scenes to be presented in a humorous way. In some cases, social aggression on television may pose more of a risk than portrayals of physical aggression do.

"These findings should help parents and educators recognize that there are socially aggressive behaviors on programs children watch. Parents should not assume that a program is okay for their child to watch simply because it does not contain physical violence. Parents should be more aware of portrayals that may not be explicitly violent in a physical sense but are nonetheless antisocial in nature," Martins said.

"Martins and Wilson's research shows just how important it is to broaden our view of 'violence' beyond the physical; particularly as their findings indicate that social violence like insults and name calling occurs just as commonly in children's programming," said Amy Jordan, director of the Media and the Developing Child sector at the University of Pennsylvania and Chair of the Children, Adolescents and the Media Division of the International Communication Association.

"As a society, we need to acknowledge that our children are learning to be socially aggressive, and that one source of this learning may be the television shows they watch. We may not see physical manifestations of this type of violence, but children who are victims of social aggression from their peers may develop deep and lasting emotional scars."

###

International Communication Association: http://Www.icahdq.org

Thanks to International Communication Association for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/123917/Social_bullying_prevalent_in_children_s_television

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FSA seeks to mend "broken" Libor, not scrap it

LONDON (Reuters) - The Financial Services Authority (FSA) delivered a 10-point plan to fix Libor but stopped short of scrapping the benchmark interest rate in a much-awaited reform of a system plagued by scandal.

"The system is broken and needs a complete overhaul," said Martin Wheatley, head of the FSA.

Wheatley acknowledged problems with London interbank offered rates, but said Libor is so deeply entrenched in the financial system that it cannot be easily replaced.

There are no better alternatives now and any transition to a new benchmark would be difficult, he said on Friday, adding that it made sense for market participants to examine whether there are other possible benchmark rates in the longer term.

The government sees the reform of Libor as critical to restoring global confidence in London as a financial centre.

"The longer the situation prevails that trust has been eroded, the more difficult it is to restore," financial services minister Greg Clark told Reuters.

The FSA plan, which includes oversight by a new panel from 2013, marks regulators' first effort to fix the tarnished benchmark, but rule makers have to thread the needle carefully.

On the one hand, they must restore confidence in the financial system; on the other, they cannot take steps that are too radical without creating big trouble with existing transactions that use the benchmark, with some home loans using Libor stretching out 65 years.

More than $300 trillion (185.2 trillion pounds) of contracts and loans ? from U.S. mortgages to Japanese interest-rate swaps - refer to Libor.

"Bringing Libor under an independent regulator will take away the notion that this was a system run by banks for the benefit of banks," said Matthew Fell, director for competitive markets at the Confederation of British Industry lobby group.

CHARGES OF MANIPULATION

Most responses to Wheatley's plan were supportive, but Stephen Gilchrist, head of regulatory law at Saunders Law, said regulation of individuals as proposed had not stopped abuses.

"The FSA only authorise persons in the financial services sector who pass a ?fit and proper' test which goes to probity and integrity. Where has that got us in the recent past?" Gilchrist said in an email.

Multiple banks have been accused of trying to manipulate Libor, a series of rates set daily in London. Barclays Plc in June agreed to pay $453 million to U.S. and British authorities to settle allegations that it tried to move Libor to help its trading positions.

Wheatley's programme for reform includes auditing banks that contribute data used to calculate the rates, to ensure they are not submitting false rates to benefit trading positions.

Libor, which is meant to reflect the rates at which banks borrow from one another, will include actual borrowing transactions. Previously, banks could estimate where they think they would borrow, which left room for manipulation.

Bank employees making Libor submissions will have to be approved by the FSA. Wheatley is looking for authorisation to criminally sanction those who attempt to manipulate the rate.

Wheatley said he had taken legal advice and does not expect a rash of legal disputes or any disruption in the transition to a new system, as there will be no change to the definition of Libor or to the timing or mechanism for submitting quotes.

Reuters parent company Thomson Reuters collects information from banks, and uses it to calculate Libor rates according to specifications drawn up by the British Bankers Association (BBA).

CULL OF RATES

The number of Libor rates will be culled from 150 to 20 with more banks required to contribute to the remaining ones.

As expected, the BBA, which had overseen the rate, will be replaced with a new, as-yet unidentified oversight panel.

The BBA said it worked closely with Wheatley on his review and had stated the need for greater regulatory oversight of Libor and tougher sanctions against manipulation.

A major remaining problem is that in financial crises, such as the one in 2008, banks cease lending to one another, effectively removing data needed to calculate Libor.

"More thought on how Libor operates during a stressed scenario is needed," said Kevin Burrowes, head of financial services at PricewaterhouseCoopers.

Mervyn King, governor of the Bank of England, said: "Over the medium to long term, further thinking will be needed to meet the challenge of benchmarks based on thinly traded markets, especially when they are quote-based."

The reforms come amid more crackdowns on the banks that submitted rates used to calculate Libor. Royal Bank of Scotland is expected to be next to settle Libor charges, with other banks to follow.

Britain's government commissioned Wheatley to report on reforming Libor and is expected to back the findings in full. Legislative changes will be inserted into a financial services bill now being approved by parliament.

(Additional reporting by Rick Rothacker in Charlotte, North Carolina and Carrick Mollenkamp and Jennifer Saba in New York; Writing by Dan Wilchins and Steve Slater; Editing by Edmund Klamann and David Holmes)

Source: http://news.yahoo.com/fsa-says-broken-libor-needs-complete-revamp-013916275--finance.html

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Mexico catches most-wanted drug trafficker, 'El Taliban'

MEXICO CITY (AP) ? Mexico appeared to strike a major blow against one faction of the hyper-violent Zetas cartel, with the navy announcing it has captured one of the country's most-wanted drug traffickers, Ivan Velazquez Caballero, known as "El Taliban."

Velazquez Caballero has been fighting a bloody internal battle with top Zetas' leader Miguel Angel Trevino Morales, and officials have said the split was behind a recent surge in massacres and shootouts, particularly in northern Mexico.

"A person who is presumed to be, and acknowledges being, Ivan Velazquez Caballero, was captured in the state of San Luis Potosi" in north-central Mexico, the navy said in a statement on Wednesday.

Officials were presenting Velazquez Caballero to the media Thursday morning.

Also known as "Z-50," Velazquez Caballero has a 30 million peso ($2.3 million) reward on his head.

If confirmed, Velazquez Caballero's arrest could calm some of the brutal violence that has hit border cities like Nuevo Laredo, across from Laredo, Texas, in recent weeks.

On Sept. 14, eight men were found shot to death and one hanging from a bridge in Nuevo Laredo, territory traditionally controlled by Trevino Morales, alias "Z-40." Analysts say 14 bullet-ridden bodies stuffed in a van in mid-August in San Luis Potosi were men loyal to "El Taliban," and may have been left there as a warning by Trevino Morales' underlings.

Discussing recent fighting, a U.S. official in Mexico who could not be named for security reason said earlier this week that "I think right now the uptick that I'm seeing is between '40' and '50'," referring to Trevino Morales and Velazquez Caballero by their "Z'' aliases.

The Zetas cartel takes its name from a police radio code in which "Z'' means "commander," and a number refers to rank.

The official said Velazquez Caballero appeared to have formed an alliance of convenience with the Knights Templar cartel based in southern Michoacan state for his fight with Trevino Morales.

Banners signed by various elements of the Zetas and hung from overpasses in several Mexican states appeared to confirm mutual hatred between Trevino Morales and Velazquez Caballero. In the obscenity-laden banners, the two capos accused each other of betraying their fellow traffickers and preying on civilians.

If the man arrested as "El Taliban" is confirmed, the development could strengthen Trevino Morales, who shares leadership of the Zetas with Heriberto Lazcano, alias "El Lazca."

The U.S. official played down recent speculation that Trevino Morales and Lazcano had also fallen out.

"I'm not familiar with a fight between him (Trevino Morales) and Lazca," the official said. "I think he and Lazca ? Lazca is doing his thing and he is doing his, and they're still together from what I understand."

Lawmen and even competing drug capos picture Trevino as a brutal assassin who favors getting rid of foes by stuffing them into oil drums, dousing them with gasoline and setting them on fire, a practice known as a "guiso," a Spanish word for "stew."

The Zetas are already considered the hemisphere's most violent criminal organization. They have been blamed for a large share of the tens of thousands of deaths in Mexico's war on drugs, though other gangs also have repeatedly committed mass slayings.

Running gun battles between Navy personnel and gunmen broke out late Wednesday in the border city of Piedras Negras, across the border from Eagle Pass, Texas.

Officials in the border state of Coahuila confirmed the shootouts, and state security spokesman Sergio Cisbeles said the confrontation was serious, but he could not immediately confirm whether there anyone was wounded or dead.

The Zetas have been known to be active in Coahuila state, but it was unclear whether the confrontations in Piedras Negras were related in any way to the capture of Velazquez Caballero.

Source: http://news.yahoo.com/mexico-catches-zetas-drug-capo-el-taliban-042724878.html

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Deadly complication of stem cell transplants reduced in mice

Deadly complication of stem cell transplants reduced in mice [ Back to EurekAlert! ] Public release date: 27-Sep-2012
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Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine

Studying leukemia in mice, researchers at Washington University School of Medicine in St. Louis have reduced a life-threatening complication of stem cell transplants, the only curative treatment when leukemia returns.

About 50 percent of leukemia patients who receive stem cells from another person develop graft-versus-host disease, a condition where donor immune cells attack the patient's own body. The main organs affected are the skin, liver and gut. Now, the scientists have shown they can redirect donor immune cells away from these vital organs. Steering immune cells away from healthy tissue also leaves more of them available for their intended purpose killing cancer cells.

"This is the first example of reducing graft-versus-host disease not by killing the T- cells, but simply by altering how they circulate and traffic," says John F. DiPersio, MD, PhD, the Virginia E. and Sam J. Golman Professor of Medicine. "Donor T-cells do good things in terms of eliminating the recipient's leukemia, but they can also attack normal tissues leading to death in a number of patients. The goal is to minimize graft-versus-host disease, while maintaining the therapeutic graft-versus-leukemia effect."

The study is now available online in Blood.

Working with mice, Jaebok Choi, PhD, research assistant professor of medicine, showed that eliminating or blocking a particular protein the interferon gamma receptor on donor T-cells makes them unable to migrate to critical organs such as the intestines but still leaves them completely capable of killing leukemia cells.

"The fact that blocking the interferon gamma receptor can redirect donor T-cells away from the gastrointestinal tract, at least in mice, is very exciting because graft-versus-host disease in the gut results in most of the deaths after stem cell transplant," DiPersio says. "People can tolerate graft-versus-host disease of the skin. But in the GI tract, it causes relentless diarrhea and severe infections due to gut bacteria leaking into the blood, which can result in severe toxicity, reduction in the quality of life or even death in some patients."

Long known to be involved in inflammation, the roles of interferon gamma, its receptor and their downstream signaling molecules are just beginning to be described in the context of graft-versus-host disease, says DiPersio, who treats patients at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.

The cascade begins when interferon gamma activates its receptor. The interferon gamma receptor then activates molecules known as JAK kinases, followed by STAT, and finally CXCR3. CXCR3 mediates the trafficking of donor T-cells to the GI tract and other target organs.

Since deleting the interferon gamma receptor from donor T-cells directs them away from target organs, the researchers asked whether they could produce the same beneficial effects by inhibiting some of the receptor's downstream signaling molecules. Indeed, Choi also found that knocking out CXCR3 reduces graft-versus- host disease, but not completely.

"There are probably additional downstream targets of interferon gamma receptor signaling other than JAKs, STATs and CXCR3 that are responsible for T-cell trafficking to the GI tract and other target organs," DiPersio says. "We're trying to figure out what those are."

To move their findings closer to possible use in humans, Choi and DiPersio also showed that they could mimic the protective effect of deleting the interferon gamma receptor with existing drugs that block JAK kinases. In this case, they tested two JAK inhibitors, one of which is currently approved by the U.S. Food and Drug Administration to treat myelofibrosis, a pre-leukemic condition in which the bone marrow is replaced with fibrous tissue.

While they showed that JAK inhibitors are effective in redirecting donor T-cells away from target organs and reducing graft-versus-host disease in mice with leukemia, they have not yet tested whether these drugs also preserve the desired anti-leukemia effect.

"The proof-of-principle behind these experiments is the exciting part," DiPersio says. "If you can change where the T-cells go as opposed to killing them, you prevent the life-threatening complications and maintain the clinical benefit of the transplant."

###

Choi J, Ziga ED, Ritchey J, Collins L, Prior JL, Cooper ML, Piwnica-Worms D, DiPersio JF. INF gamma receptor signaling mediates alloreactive T cell trafficking and GvHD. Blood. Online Sept. 12, 2012.

This work was supported by grants from the National Cancer Institute (R01 CA83845 and R21 grants CA110489, CA132269, CA141523 P01 CA101937, P50 CA94056, the Bryan Thomas Campbell Foundation, the Molecular Imaging Center Pilot Research Project 2010 Awards (P50 CA94056), the Translational Oncology Group at the Washington University School of Medicine, the Siteman Cancer Center Research Development Awards in Developmental Therapeutics, and the American Cancer Society Institutional Research Grant (IRG-58-010-53).

Washington University School of Medicine's 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked sixth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.


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Deadly complication of stem cell transplants reduced in mice [ Back to EurekAlert! ] Public release date: 27-Sep-2012
[ | E-mail | Share Share ]

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine

Studying leukemia in mice, researchers at Washington University School of Medicine in St. Louis have reduced a life-threatening complication of stem cell transplants, the only curative treatment when leukemia returns.

About 50 percent of leukemia patients who receive stem cells from another person develop graft-versus-host disease, a condition where donor immune cells attack the patient's own body. The main organs affected are the skin, liver and gut. Now, the scientists have shown they can redirect donor immune cells away from these vital organs. Steering immune cells away from healthy tissue also leaves more of them available for their intended purpose killing cancer cells.

"This is the first example of reducing graft-versus-host disease not by killing the T- cells, but simply by altering how they circulate and traffic," says John F. DiPersio, MD, PhD, the Virginia E. and Sam J. Golman Professor of Medicine. "Donor T-cells do good things in terms of eliminating the recipient's leukemia, but they can also attack normal tissues leading to death in a number of patients. The goal is to minimize graft-versus-host disease, while maintaining the therapeutic graft-versus-leukemia effect."

The study is now available online in Blood.

Working with mice, Jaebok Choi, PhD, research assistant professor of medicine, showed that eliminating or blocking a particular protein the interferon gamma receptor on donor T-cells makes them unable to migrate to critical organs such as the intestines but still leaves them completely capable of killing leukemia cells.

"The fact that blocking the interferon gamma receptor can redirect donor T-cells away from the gastrointestinal tract, at least in mice, is very exciting because graft-versus-host disease in the gut results in most of the deaths after stem cell transplant," DiPersio says. "People can tolerate graft-versus-host disease of the skin. But in the GI tract, it causes relentless diarrhea and severe infections due to gut bacteria leaking into the blood, which can result in severe toxicity, reduction in the quality of life or even death in some patients."

Long known to be involved in inflammation, the roles of interferon gamma, its receptor and their downstream signaling molecules are just beginning to be described in the context of graft-versus-host disease, says DiPersio, who treats patients at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.

The cascade begins when interferon gamma activates its receptor. The interferon gamma receptor then activates molecules known as JAK kinases, followed by STAT, and finally CXCR3. CXCR3 mediates the trafficking of donor T-cells to the GI tract and other target organs.

Since deleting the interferon gamma receptor from donor T-cells directs them away from target organs, the researchers asked whether they could produce the same beneficial effects by inhibiting some of the receptor's downstream signaling molecules. Indeed, Choi also found that knocking out CXCR3 reduces graft-versus- host disease, but not completely.

"There are probably additional downstream targets of interferon gamma receptor signaling other than JAKs, STATs and CXCR3 that are responsible for T-cell trafficking to the GI tract and other target organs," DiPersio says. "We're trying to figure out what those are."

To move their findings closer to possible use in humans, Choi and DiPersio also showed that they could mimic the protective effect of deleting the interferon gamma receptor with existing drugs that block JAK kinases. In this case, they tested two JAK inhibitors, one of which is currently approved by the U.S. Food and Drug Administration to treat myelofibrosis, a pre-leukemic condition in which the bone marrow is replaced with fibrous tissue.

While they showed that JAK inhibitors are effective in redirecting donor T-cells away from target organs and reducing graft-versus-host disease in mice with leukemia, they have not yet tested whether these drugs also preserve the desired anti-leukemia effect.

"The proof-of-principle behind these experiments is the exciting part," DiPersio says. "If you can change where the T-cells go as opposed to killing them, you prevent the life-threatening complications and maintain the clinical benefit of the transplant."

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Choi J, Ziga ED, Ritchey J, Collins L, Prior JL, Cooper ML, Piwnica-Worms D, DiPersio JF. INF gamma receptor signaling mediates alloreactive T cell trafficking and GvHD. Blood. Online Sept. 12, 2012.

This work was supported by grants from the National Cancer Institute (R01 CA83845 and R21 grants CA110489, CA132269, CA141523 P01 CA101937, P50 CA94056, the Bryan Thomas Campbell Foundation, the Molecular Imaging Center Pilot Research Project 2010 Awards (P50 CA94056), the Translational Oncology Group at the Washington University School of Medicine, the Siteman Cancer Center Research Development Awards in Developmental Therapeutics, and the American Cancer Society Institutional Research Grant (IRG-58-010-53).

Washington University School of Medicine's 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children's hospitals. The School of Medicine is one of the leading medical research, teaching and patient care institutions in the nation, currently ranked sixth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children's hospitals, the School of Medicine is linked to BJC HealthCare.


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Source: http://www.eurekalert.org/pub_releases/2012-09/wuso-dco092712.php

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